Home CONTACT Acta Virologica 2003 Acta Virologica Vol.47, p.53-56, 2003

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.47, p.53-56, 2003

Title: COMBINED PROTECTIVE EFFECT OF A FUNGAL CU/ZN-CONTAINING SUPEROXIDE DISMUTASE AND RIMANTADINE HYDROCHLORIDE IN EXPERIMENTAL MURINE INFLUENZA A VIRUS INFECTION
Author: J. Serkedjieva, I. Roeva, M. Angelova, P. Dolashka, W.g. Voelter

Abstract: The combined protective effect of a novel naturally glycosylated Cu/Zn-containing superoxide dismutase, produced by the fungus Humicula lutea (HL-SOD) strain 103, and the selective anti-influenza drug rimantadine hydrochloride (Rim) was evaluated in experimental virus infection in mice, induced with influenza virus A/Aichi/2/68 (H3N2). A combined application of HL-SOD and Rim in doses, which by themselves did not protect significantly mice against the infection, resulted in a synergistically increased protection, determined on the basis of protective indices. Lung virus titers, lung weights and consolidation and mortality rates were all decreased significantly, while survival times were prolonged.

Keywords: fungus Humicula lutea; superoxide dismutase, rimantadine hydrochloride, combined protective effect, murine influenza virus infection
Year: 2003, Volume: 47, Issue: Page From: 53, Page To: 56



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