Home CONTACT Neoplasma 2007 Neoplasma Vol.54, p.127-130, 2007

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.127-130, 2007

Title: Hsp90 inhibitor Geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin
Author: P. SOLAR, V. HORVATH, J. KLEBAN, J. KOVAL, Z. SOLAROVA, A. KOZUBIK, P. FEDOROCKO

Abstract: Ovarian carcinoma is the leading cause of death among gynecological neoplasms in the world. The chemoresistance is a major obstacle in the effective treatment of ovarian and other cancers. We evaluated the effects of Hsp90 inhibitor geldanamycin (GEL) alone and in combination with cisplatin in cisplatin resistant ovarian adenocarcinoma cell line. Our results showed Akt depletion and S-phase arrest of A2780cis cells after GEL treatment. Combined exposure of A2780cis cells to GEL and cisplatin resulted in greater than additive cytotoxic effect.

Keywords: chemoresistance, cisplatin, A2780cis, Hsp90, geldanamycin
Year: 2007, Volume: 54, Issue: Page From: 127, Page To: 130

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