Home FOR AUTHORS Neoplasma 2007 Neoplasma Vol.54, p.162-167, 2007

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Neoplasma Vol.54, p.162-167, 2007

Title: Arterial blood pressure and baroreflex sensitivity 1 – 18 years after completing anthracycline therapy
Author: Z. NOVAKOVA, P. BALCARKOVA, N. HONZIKOVA, B. FISER, E. ZAVODNA, H. HRSTKOVA, K. KRONTORADOVA, J. STASTNA

Abstract: The analysis of short-term blood pressure regulation in children, adolescents and young adults 1 to 18 years after the treatment with anthracyclines known to have cardiotoxic side effects for oncological diseases was the aim of the present study. Thirty-one subjects treated with anthracyclines (PA) and 11 subjects treated with different antitumour drugs (P0) were investigated twice (the interval between two investigations 1 – 9 years). Three hundred and thirty-nine healthy subjects served as controls (C). Systolic (SBP), diastolic blood pressures (DBP) in the finger arteries and inter-beat interval (IBI) were recorded beat-tobeat (FINAPRES, Ohmeda, metronome controlled breathing, 5 minute recording); the values were corrected by auscultatory blood pressure measurements. Baroreflex sensitivity (BRS, ms/mmHg) was determined by a spectral method. As the investigated subjects were of different ages, the measured values were standardised on the age of 16 years by linear regression, and only standardised values (IBI16, SBP16, DBP16 and BRS16) were further analysed. No differences were found between PA, P0 and C in BRS16 and IBI16. SBP16 and DBP16 were significantly lower in PA (102.1±8.3/59.7±7.1 versus C: 114.1±12.4/69.0±9.5 mmHg; p

Keywords: Anthracyclines – Baroreflex sensitivity – Blood pressure – Cardiotoxicity
Year: 2007, Volume: 54, Issue: Page From: 162, Page To: 167

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