Home CONTACT Neoplasma 2007 Neoplasma Vol.54, p.173-179, 2007

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.173-179, 2007

Title: Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin.
Author: P. WLODARSKI, C. SEVIGNANI, M. J. FERNANDES, B. CALABRETTA, K. H. WLODARSKI

Abstract: Excessive bone formation occurring in such conditions as paravertebral ligamentous ossification, hallux osteophytes or some neoplastic tumors, presents a significant problem, both epidemiological and clinical. Since pathogenesis of this disorder is still unclear, we studied its mechanism in experimental model utilizing inducible orthotopic osteogenesis. Periosteal bone apposition stimulated by Moloney sarcoma is characterized by unusually high volume of new bone tissue appearing subperiosteally in the bone adjacent to the tumor. Genes engaged in this growth have not been characterized so far. Here we show the results of mRNA Representation Difference Analysis in Moloney sarcoma, which reveal high expression of four genes coding extracellular matrix proteins: osteopontin, fibronectin, stromelysin-1 and tenascin. These findings suggest that the uncommon dynamics of the Moloney sarcoma –induced osteogenesis depends on high expression of these extracellular matrix proteins.

Keywords: orthotopic osteogenesis, stromelysin-1, MMP-3, fibronectin, osteopontin, tenascin, Murine Moloney sarcoma virus, Mu-MSV.
Year: 2007, Volume: 54, Issue: Page From: 173, Page To: 179

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