Neoplasma Vol.54, p.379-382,

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.379-382,
Title: Tissue detection of natural killer cells in laryngeal carcinoma
Author: A. C. LAZARIS, J. V. SEGAS, T. P. NIKOLOPOULOS, E. S. PATSOURIS

Abstract: Natural Killer (NK) cells have gained much attention as potential cells in antitumor immune defense mechanisms. In a group of 31 patients with surgically treated squamous cell laryngeal carcinoma, NK cell presence was semiquantitatively assessed by means of immunohistochemistry. A panel of three monoclonal antibodies including anti-CD16, was applied on frozen tissue sections. High CD 16+ cell presence was more frequently detected in poorly differentiated carcinomas (in 6 out of 14 cases) by comparison to carcinomas of high to moderate degrees of differentiation (in 1 out of 16 cases, p=0.031). No other clinicopathological variable appeared to influence NK cell presence in the examined specimens. No relation between NK cell detection and relapse-free survival emerged. Poorly differentiated laryngeal cancer cells appear to trigger off a greater NK cell tissue response than well and moderately differentiated cancer cells; however, the potential prognostic impact of this observation remains to be established.

Keywords: Natural killer cells; laryngeal cancer; immunohistochemistry
Year: 2007, Volume: 54, Issue:	Page From: 379, Page To: 382


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