Home Neoplasma 2007 Neoplasma Vol.54, p.447-453,

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.54, p.447-453,

Title: Preoperative Radiotherapy and Concomitant Capecitabine Treatment Induce Thymidylate Synthase and Thymidine Phosphorylase mRNAs in Rectal Carcinoma
Author: I. KOCAKOVA, M. SVOBODA, K. KUBOSOVA, V. CHRENKO, E. ROUBALOVA, E. KREJCI, R. SEFR, P. SLAMPA, T. FRGALA, J. ZALOUDIK

Abstract: This work is intended to study the effect of preoperative capecitabine and radiotherapy treatment on the levels of thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) mRNAs in rectal carcinoma. 55 patients with locally advanced rectal carcinoma (cT3-4, N0, M0 or cT2-4,N+, M0) were treated with capecitabine 825 mg/m2 twice a day and pelvic radiotherapy 1,8 Gy daily up to cumulative dose of 45 Gy, boosting up to 50,4 Gy. Patients underwent surgery 6th week after the completion of chemoradiotherapy. Biopsies of rectal carcinoma were taken before starting therapy and 14 days after its cesation. Biopsies were examined for TS, DPD and TP mRNA levels. CEA in serum was examined to monitor relapses. Both TP and TS mRNA increase two weeks after starting therapy (p

Keywords: Thymidine Phosphorylase Induction, Thymidylate Synthase, Preoperative Chemoradiotherapy, Capecitabine, Rectal Cancer
Year: 2007, Volume: 54, Issue: Page From: 447, Page To: 453

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