Home Neoplasma 2008 Neoplasma Vol.55, No.2, p.081-086, 2008

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.55, No.2, p.081-086, 2008

Title: α-Lipoic acid – the potential for use in cancer therapy

Abstract: This review deals with alpha-lipoic acid (LA) from the point of its chemical and biological characteristics affecting enzymatic activities that are part of cellular biochemical processes in normal and cancer cells. This includes attributes of LA that are related to its ability to act as a free-radicals scavenger and also as a radical generator. LA is discussed in the light of its physico-chemical features, toxicity, biochemical bases of LA biological activities, and mechanisms of action. Additionally, it is discussed how these properties of LA are reflected by results of in vivo experiments with cancer cells and in experimental cancer chemotherapy. Finally, the results of LA use in human cancer chemotherapy and as chemopreventive agent are discussed in the light of LA future inclusion into chemotherapeutic protocols.

Keywords: Lipoic acid, cancer therapy, mechanism of action, biological activity, cancer prevention
Year: 2008, Volume: 55, Issue: 2 Page From: 81, Page To: 86

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