Home Neoplasma 2008 Neoplasma Vol.55, No.2, p.107-112, 2008

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.55, No.2, p.107-112, 2008

Title: Autologous stem cell transplantation in first-line treatment of high-risk aggressive non-Hodgkin’s lymphoma

Abstract: A single center, retrospective analysis evaluating the outcome of patients with poor-risk aggressive non-Hodgkin’s lymphoma (NHL) treated with high-dose chemotherapy and autologous stem cell transplantation (ASCT) as a part of firstline therapy. Forty-seven patients younger than 65 years with diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL) or alk-negative anaplastic large cell lymphoma (ALCL) underwent ASCT between July 1997 and November 2005. Patients with DLBCL and alk-negative ALCL had 2 or 3 age-adjusted International Prognostic Index risk factors. All patients were transplanted after MACOP-B induction therapy followed by 2 courses of DHAP and myeloablative chemotherapy BEM or CBV. The complete response rate to the high-dose therapy was 79% with an estimated 5-year progression-free survival of 66%. At a median follow-up of 35 months (range, 16 to 112 months) the estimated overall survival at five years was 59%. There were 4 treatment-related deaths. Twenty-nine of 47 patients remain in complete remission. Our results confirm the efficacy of high-dose therapy with ASCT during first-line treatment of patients with poor-prognosis aggressive lymphoma, with substantial number of patients cured by using this treatment approach.

Keywords: high-dose chemotherapy; autologous transplantation, aggressive non-Hodgkin’s lymphoma
Year: 2008, Volume: 55, Issue: 2 Page From: 107, Page To: 112

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