Home Neoplasma 2008 Neoplasma Vol.55, No.6, p.507-512, 2008

Journal info

6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.55, No.6, p.507-512, 2008

Title: Expression of cyclin A in intestinal biopsies from children with celiac disease

Abstract: The aim of this study was to determine the expression of cyclin A and describe its distribution in biopsy samples taken from children with suspected and confirmed celiac disease as well as in control samples. Investigated material consisted of 37 intestinal biopsies: 19 taken from patients with confirmed celiac disease, 9 from patients with its suspicion and 9 from healthy patients, who served as control. Immunohistochemical and immunogold methods were used to estimate cyclin A expression. In celiac disease samples morphological changes in epithelial cells, typical for disease, were shown. We observed weaker cyclin A expression, however there were also some cells with strong labeling in cytoplasm, near the nucleus. In control and suspected celiac disease groups cyclin A was present in the brush border, nucleus and whole cytoplasm, especially in proximity to the nucleus. In conclusion, these studies enabled us visualized pattern of distribution of cyclin A but let us also to presume that observed decrease of expression and its distribution might function as additional factor which could be taken under consideration to establish terminal diagnosis. We are aware of the fact that these are very first observations and that this subject needs to be further investigated with the use of additional methods and samples.

Keywords: celiac disease, cyclin A, immunogold, immunohistochemistry
Year: 2008, Volume: 55, Issue: 6 Page From: 507, Page To: 512

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.