Home Acta Virologica 2005 Acta Virologica Vol.49, p.159-167, 2005

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.49, p.159-167, 2005


Abstract: Immune responses against productive Herpes simplex virus 1 (HSV-1) and/or Herpes simplex virus 2 (HSV-2) (HSV) infection together with associated immune escape mechanisms are to a great degree understood. Due to a limited RNA expression and lacking a convincing evidence for production of virus proteins during latency, HSV in latently infected neurons had been for a long period considered invisible to immune system. This review analyzes currently accumulating data indicating an important role of immune response to HSV-1 latency and/or to early steps of HSV-1 reactivation process. Although this review focuses on HSV-1, it is likely that general concepts apply to both HSV-1 and HSV-2, since they share a great deal of similarity in their biological features including a high degree of sequence similarity at the nucleic acid level.

Keywords: Herpes simplex virus 1; Herpes simplex virus 2; latency; latency-associated transcripts, latencyassociated proteins, CD8+T cell
Year: 2005, Volume: 49, Issue: Page From: 159, Page To: 167

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