Acta Virologica Vol.49, p.207-210, 2005

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.49, p.207-210, 2005
Title: DEVELOPMENT OF RABIES DNA VACCINE USING A RECOMBINANT PLASMID
Author: N. RAI, P. KAUSHIK, A. RAI

Abstract: A recombinant plasmid pTargeT.rabgp containing the glycoprotein (G) gene of Rabies virus (RV) was constructed and produced for immunogenicity studies on mice and dogs. The mice immunized twice with 50 μg or 100 μg of pTargeT.rabgp intramuscularly (i.m.), showed a serum antibody titer of 256 or 64, respectively 14 days post immunization (p.i.). When the vaccinated mice were challenged at 14 days p.i. with RV i.c., they were protected in 81.25% or 87.5%, respectively. A positive cell mediated immune response was observed by lymphocyte proliferation assay and macrophage migration inhibition test. These results indicate that the pTargeT.rabgp plasmid can be used as a rabies DNA vaccine.

Keywords: Rabies virus; DNA vaccine; glycoprotein gene; protection; neutralization test; antibody titer
Year: 2005, Volume: 49, Issue:	Page From: 207, Page To: 210


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