Home CONTACT Acta Virologica 2005 Acta Virologica Vol.49, p.207-210, 2005

Journal info


Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Aims and Scope
Editorial Info

Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.49, p.207-210, 2005

Title: DEVELOPMENT OF RABIES DNA VACCINE USING A RECOMBINANT PLASMID
Author: N. RAI, P. KAUSHIK, A. RAI

Abstract: A recombinant plasmid pTargeT.rabgp containing the glycoprotein (G) gene of Rabies virus (RV) was constructed and produced for immunogenicity studies on mice and dogs. The mice immunized twice with 50 μg or 100 μg of pTargeT.rabgp intramuscularly (i.m.), showed a serum antibody titer of 256 or 64, respectively 14 days post immunization (p.i.). When the vaccinated mice were challenged at 14 days p.i. with RV i.c., they were protected in 81.25% or 87.5%, respectively. A positive cell mediated immune response was observed by lymphocyte proliferation assay and macrophage migration inhibition test. These results indicate that the pTargeT.rabgp plasmid can be used as a rabies DNA vaccine.

Keywords: Rabies virus; DNA vaccine; glycoprotein gene; protection; neutralization test; antibody titer
Year: 2005, Volume: 49, Issue: Page From: 207, Page To: 210

Price: 7.20 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.