Home Acta Virologica 2006 Acta Virologica Vol.50, p.45-51, 2006

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.50, p.45-51, 2006

Title: MOLECULAR CHARACTERIZATION OF RECENT INFECTIOUS BURSAL DISEASE VIRUS ISOLATES FROM MALAYSIA
Author: I. NURULFIZA, M. HAIR-BEJO, A.R. OMAR, I. AINI

Abstract: Three isolates of Infectious bursal disease virus (IBDV), designated UPM04178, UPM04190 and UPM04238, were obtained from severe outbreaks of infectious bursal disease (IBD) in Malaysia in 2004. The hypervariable region (HPVR) of VP2 gene of these isolates was sequenced. The obtained sequences were compared with those of other isolates. The highest similarity (98%) concerning both nucleotide and amino acid sequences was found to very virulent IBDV (vvIBDV) strains. Phylogenetic analysis revealed clustering of the three isolates with vvIBDV strains. Evolutionary relatedness of the three isolates to vvIBDV strains was demonstrated by three phylogenetic methods: bootstrap values of 100%, 95% and 90% for nucleotide sequences and those of 58%, 86% and 96% for amino acid sequences were obtained by the distance, maximum parsimony and maximum likehood methods, respectively. It is concluded that UPM04178, UPM04190 and UPM04238 are vvIBDV isolates of serotype 1, which originate from a common ancestor of IBDV strains present in Malaysia.

Keywords: Infectious bursal disease virus; RT-PCR; VP2 gene; hypervariable region; phylogenetic analysis; sequencing
Year: 2006, Volume: 50, Issue: Page From: 45, Page To: 51



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