Home Acta Virologica 2008 Acta Virologica Vol.52, No.4, p.225-229, 2008

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.52, No.4, p.225-229, 2008

Title: Intranasal immunization of mice with VP2 dna of human rotavirus A induces cellular and humoral immunity
Author: F. Pourasgari, S. Ahmadian, Z. M. Hassan, M. Mahdavi, A. H. Salmanian, M. N. Sarbolouki, P. Pothier


DNA vaccination using a plasmid encoding Human rotavirus A (HuRV-A) inner capsid VP2 was examined in a mouse model. BALB/c mice were immunized intranasally (i.n.) with a VP2 DNA vaccine that induced cellular and humoral immune response to HuRV-A. The increased levels of cytokines IFN-g and IL-4 and the production of anti-VP2 IgG antibodies were detected. In addition, splenocyte proliferation detected by MTT test was enhanced in the mice treated with the vaccine. These results may encourage the development of a HuRV-A DNA vaccine derived from the inner layer of viral capsid that can be administered i.n.

Keywords: Human rotavirus A; VP2 protein; immunogenicity; DNA vaccine; mouse
Year: 2008, Volume: 52, Issue: 4 Page From: 225, Page To: 229

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