Home HOME Acta Virologica 2008 Acta Virologica Vol.52, No.4, p.261-264, 2008

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.52, No.4, p.261-264, 2008

Title: Prevalence of a 32 bp deletion in the gene for human immunodeficiency virus 1 co-receptor CCR5 in Slovak population
Author: M. Takacova, P. Nogova, M. Habekova, D. Stanekova

Abstract:

The chemokine (C-C motif) receptor 5 (CCR5) represents a major co-receptor for macrophage-tropic Human immunodeficiency virus 1 (HIV-1) strains. A 32 bp deletion mutant allele in the CCR5 gene (CCR5-D32) provides to homozygotes a strong resistance to HIV-1 infection. In this study, the prevalence of CCR5-D32 in 200 HIV-1-negative and 162 HIV-1-positive individuals was determined. The presence of CCR5-D32 in blood samples was detected by PCR. CCR5-D32 was found to be homozygous in 1% and heterozygous in 17% of the HIV-1-negative individuals. In HIV-1-positive patients, no homozygous CCR5-D32 was found, while heterozygous CCR5-D32 occurred in 15.4% patients. Thus, no significant difference between HIV-1-negative and HIV-1-positive individuals was found, what is in accord with the findings obtained in other EU countries. The results of this study do not indicate that a relatively low incidence of HIV-1 infection in Slovakia could be caused by the CCR5-D32 mutation.



Keywords: Human immunodeficiency virus 1; CCR5 co-receptor; D32 mutation; Slovakia
Year: 2008, Volume: 52, Issue: 4 Page From: 261, Page To: 264

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