Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Acta Virologica Vol.52, No.4, p.261-264, 2008 |
||
Title: Prevalence of a 32 bp deletion in the gene for human immunodeficiency virus 1 co-receptor CCR5 in Slovak population | ||
Author: M. Takacova, P. Nogova, M. Habekova, D. Stanekova | ||
Abstract: The chemokine (C-C motif) receptor 5 (CCR5) represents a major co-receptor for macrophage-tropic Human immunodeficiency virus 1 (HIV-1) strains. A 32 bp deletion mutant allele in the CCR5 gene (CCR5-D32) provides to homozygotes a strong resistance to HIV-1 infection. In this study, the prevalence of CCR5-D32 in 200 HIV-1-negative and 162 HIV-1-positive individuals was determined. The presence of CCR5-D32 in blood samples was detected by PCR. CCR5-D32 was found to be homozygous in 1% and heterozygous in 17% of the HIV-1-negative individuals. In HIV-1-positive patients, no homozygous CCR5-D32 was found, while heterozygous CCR5-D32 occurred in 15.4% patients. Thus, no significant difference between HIV-1-negative and HIV-1-positive individuals was found, what is in accord with the findings obtained in other EU countries. The results of this study do not indicate that a relatively low incidence of HIV-1 infection in Slovakia could be caused by the CCR5-D32 mutation. |
||
Keywords: Human immunodeficiency virus 1; CCR5 co-receptor; D32 mutation; Slovakia | ||
Year: 2008, Volume: 52, Issue: 4 | Page From: 261, Page To: 264 | |
Price:
9.60 €
|
||
|
||