Acta Virologica Vol.47, p.73-77, 2003

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.47, p.73-77, 2003
Title: SEQUENCE ANALYSIS OF SEGMENT A OF A FIELD VIRUS ISOLATE FROM AN OUTBREAK OF INFECTIOUS BURSAL DISEASE IN INDIA
Author: M.V. Bais, R.S. Kataria, A.K. Tiwari, Indervesh, V.V S. Suryanarayana, S.K. Das

Abstract: Sequence analysis of genome segment A of an Indian Infectious bursal disease virus (IBDV) field isolate (KT1/99) revealed total 95 nucleotide substitutions, resulting in 17 amino acid changes. Of these, five amino acid changes, namely F60S, T137I, I374V, V519I and E682D were unique to the KT1/99 isolate. The amino acid change P222A and the proposed hot mutation spot 680Y, reported to be present in very virulent IBDV isolates were also found in KT1/99. This isolate had nucleotide divergence of 1.1% to 4.95% from the other reported serotype 1 IBDV isolates and 19.6% from serotype 2 strain OH in polyprotein gene sequence, while divergence at amino acid level was 0.6% to 2.9% and 11.4%, respectively. Based on both nucleotide and amino acid sequence analysis, KT1/99 was grouped phylogenetically with the reported Bangladesh isolate BD3/99 in one cluster along with other reported very virulent isolates in same lineage.

Keywords: Infectious bursal disease virus; nucleotide sequence; amino acid sequence; segment A
Year: 2003, Volume: 47, Issue:	Page From: 73, Page To: 77


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