Home Acta Virologica 2006 Acta Virologica Vol.50, p.139-143, 2006

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.50, p.139-143, 2006

Title: ASSESSMENT OF EFFICACY OF A LIVE ORAL POLIOVIRUS VACCINE FOR VIRULENT SABIN-LIKE POLIOVIRUS 1 STRAINS IN JAPAN
Author: M. IWAI, T. NAKAYAMA, K. MATSUURA, S. HASEGAWA, S. ANDO, M. OBARA, Y. NAGAI, H. YOSHIDA, H. HORIE

Abstract: Virulent Sabin-like poliovirus (VSLP) was isolated from river and sewage waters between October 1993 and September 1995 in Toyama Prefecture, Japan (Yoshida et al., Lancet 356, 1461–1463, 2000). In this study, to assess the possibility of an epidemic of poliomyelitis caused by a VSLP in Japan under the current vaccination policy of administration of live attenuated oral poliovirus vaccine (OPV), we determined titers of serum neutralizing antibodies to poliovirus 1 (PV-1) strains Sabin (vaccine strain), Mahoney (wildtype strain) and G4-12 (VSLP) in various groups of residents of Toyama Prefecture, Japan. The seropositivity and geometric mean neutralizing antibody titers against these strains in the individuals who obtained two doses of OPV were 99.1%, 94.5% and 95.5%, respectively, and 564, 186 and 194, respectively. Although the antibody titers to G4-12 were lower compared with those to Sabin, these results indicate that the OPV vaccination policy in Japan has been effective in preventing poliomyelitis caused by VSLPs. These results also suggest that (i) an epidemic of poliomyelitis caused by a VSLP has not occurred in Japan due to herd immunity, and (ii) the possibility of reemergence of VSLPs will be prevented if sufficient herd immunity is acquired immediately after completion of the OPV vaccination in accordance with the poliomyelitis eradication program.

Keywords: poliovirus 1; poliomyelitis; oral poliovirus vaccine; inactivated poliovirus vaccine; virulent Sabin-like poliovirus
Year: 2006, Volume: 50, Issue: Page From: 139, Page To: 143



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