Home Acta Virologica 2006 Acta Virologica Vol.50, p.151-162, 2006

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.50, p.151-162, 2006

Title: THE ROLE OF CYTOKINES IN THE IMMUNE RESPONSE TO INFLUENZA A VIRUS INFECTION
Author: T. SLÁDKOVÁ, F. KOSTOLANSKÝ

Abstract: Influenza A virus is one of the most important causes of respiratory tract diseases. It replicates in epithelial cells and leukocytes resulting in the production of immune mediators – cytokines, substances with various biological effects. Cytokines, as a part of innate immunity, favor the development of antiviral and TH1-type immune responses. Cytokines also affect the adaptive immune response and disease manifestation. In the organism, the virus infection results in the production of chemotactic [a regulated upon activation, normal T cell-expressed and -secreted cytokine (RANTES), monocyte chemoattractant proteins (MCP) MCP-1, MCP-3, macrophage inflammatory protein 1α (MIP-1α), interferon γ-induced protein 10 (IP-10), and interleukin 8 (IL-8)], pro-inflammatory [IL-1β, IL-6, IL-18, and tumor necrosis factor α(TNF-α)] and antiviral [interferon (IFN) α/β] cytokines. Whilst knowledge of the mechanisms underlying host and tissue specificity has advanced significantly, we still know relatively little about the function of cytokines released from different cells following influenza infection. In this review we deal with the role and mode of possible impact of cytokines on the disease pathogenesis and host immune response.

Keywords: cytokines; immunity; influenza; Influenza A virus; pathogenesis
Year: 2006, Volume: 50, Issue: Page From: 151, Page To: 162



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