Acta Virologica Vol.50, p.187-193, 2006

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.50, p.187-193, 2006
Title: pH MODULATING ACTIVITY OF ION CHANNELS OF INFLUENZA A, B, AND C VIRUSES
Author: T. BETÁKOVÁ, E. KOLLEROVÁ

Abstract: The BM2 and NB proteins of Influenza B virus (the B virus) and the CM2 protein of Influenza C virus (the C virus) are structural homologs of the M2 protein of Influenza A virus (the A virus). It was shown recently that CM2 in vitro forms a voltage-activated ion channel permeable to chloride ion (Hongo et al., Arch. Virol. 149, 35–50, 2004). To demonstrate a possible pH modulating activity of BM2, NB and CM2, the latters were co-expressed with a pH-sensitive hemagglutinin (HA) of the A virus. BM2 was able to replace functionally M2 and prevented the A virus HA from adopting its low-pH conformation during transport to the cell surface. In contrast, NB had a negative effect on the quality of the co-expressed HA and was unable to modulate the pH in the trans-Golgi network (TGN) and to protect HA. A pH modulating activity was also demonstrated for CM2, but it was much lower than that of M2.

Keywords: BM2 protein; CM2 protein; influenza viruses; hemagglutinin; M2 protein; NB protein; ion channel
Year: 2006, Volume: 50, Issue:	Page From: 187, Page To: 193


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