Home HOME Acta Virologica 2006 Acta Virologica Vol.50, p.251-256, 2006

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.50, p.251-256, 2006

Title: COEXPRESSION OF INTERLEUKIN-2 ENHANCES THE IMMUNIZATION EFFECT OF A DNA VACCINE EXPRESSING HERPES SIMPLEX 1 GLYCOPROTEIN D
Author: W.-R. LI, B. NIU, J.-W. WANG, Z.-J. FENG, D.-X. WANG

Abstract: Summary. – In this study, DNA vaccines consisting of vector IRES-gD expressing Herpes simplex virus 1 (HSV-1) glycoprotein D (gD) and vector IRES-gD-IL-2 coexpressing HSV-1 gD and interleukin-2 (IL-2), respectively, were constructed. After intramuscular inoculation, both vaccines induced in BALB/c mice antibodies as assayed by ELISA and virus neutralization. However, IRES-gD-IL-2 elicited significantly higher levels of IgG (ELISA) and neutralizing antibodies than IRES-gD. Isotyping of sera from mice injected with IRES-gD-IL-2 revealed predominately IgG2a antibodies. IRES-gD-IL-2 also elicited a higher delayed-type sensitivity (DTH) reaction. However, there was no difference in the protection against lethal challenge with HSV-1 between the two vaccines (P>0.05). The results suggest that the vaccination with IRES-gD-IL-2 can efficiently enhance the immune response of mice to HSV-1, particularly through increased cellular immunity.

Keywords: Herpes simplex virus 1; glycoprotein D; interleukin-2; DNA vaccine
Year: 2006, Volume: 50, Issue: Page From: 251, Page To: 256

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