Home Acta Virologica 2006 Acta Virologica Vol.50, p.257-261, 2006

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.50, p.257-261, 2006

Title: PrP GENE POLYMORPHISM IN SHEEP BREEDS IN SLOVAKIA AND SUSCEPTIBILITY TO SCRAPIE
Author: Ľ. TKÁČIKOVÁ, G. ROLKOVÁ, J. BÍREŠ, P. NOVÁK, E. KONTSEKOVÁ, D. IMRICHOVÁ, M. BHIDE, E. HANUŠOVSKÁ, I. MIKULA, M. NOVÁK

Abstract: Summary. – We analyzed the prion protein (PrP) genotype based on the codons 136, 154 and 171 and assigned to five risk groups (R1-R5) in healthy and scrapie-affected sheep in Slovakia. In healthy (asymptomatic) population, 119 Merino, 106 Improved Valachian, 117 Tsigai, and 48 Suffolk breeds were tested. Among the asymptomatic sheep, the low-risk genotypes R1 and R2 were most abundant in Suffolk (94%) and Merino (84%) breeds, followed by Tsigai (58%) and Improved Valachian (40%) breeds. The medium-risk group R3 was most frequent in Improved Valachian (31%) breed, followed by Tsigai (21%), Merino (10%), and Suffolk (6%) breeds. The occurrence of high-risk groups R4 and R5 was none in Suffolk breed, followed by Merino (6%), Tsigai (21%), and Improved Valachian (30%) breeds. Since 2003, altogether 48 cases of scrapie have been confirmed in Tsigai (38), Merino (4), Improved Valachian (2), Improved Valachian x Tsigai (3), and Suffolk (1) breeds. Among sheep with scrapie, Merino breed belonged to the medium-risk group R3. The majority of scrapie-affected Tsigai sheep were classified into high-risk R5 (50%) and medium-risk R3 (42%) groups. We showed an association of scrapie with medium- and high-risk groups of PrP genotype in Slovakia. In particular, the glutamine at position 171 appears to be of major importance for the susceptibility to scrapie.

Keywords: scrapie; PrP; polymorphism; prion; sheep breeds
Year: 2006, Volume: 50, Issue: Page From: 257, Page To: 261

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