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Acta Virologica Vol.51, p.13-20, 2007 |
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Title: REACTIVATION OF LATENT HUMAN IMMUNODEFICIENCY VIRUS 1 BY HUMAN HERPESVIRUS 6 INFECTION | ||
Author: Y. ISEGAWA, J. KATAHIRA, K. YAMANISHI, N. SUGIMOTO | ||
Abstract: Infection of the ACH-2 line of human leukemic T cells carrying latent Human immunodeficiency virus 1 (HIV-1) with Human herpesvirus 6 (HHV-6) resulted in an increase in reverse transcriptase (RT) activity, a marker of HIV-1 activation, in the culture supernatant. A similar effect was obtained with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The RT activity reached a peak at 24 hrs post infection (p.i.) and then declined, suggesting that the cells underwent lysis. The HIV-1 antigen was co-expressed with an early-late HHV-6 product, but not always with an immediate-early (IE) HHV-6 product, suggesting that one or more IE gene products were involved in the activation of latent HIV-1 in ACH-2 cells. |
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Keywords: Human herpesvirus 6; Human immunodeficiency virus 1; reactivation, latent infection | ||
Year: 2007, Volume: 51, Issue: | Page From: 13, Page To: 20 | |
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