Home General Physiology and Biophysics 2008 General Physiology and Biophysics Vol.27, p.291-298, 2008

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.27, p.291-298, 2008

Title: The effect of simvastatin on coenzyme Q and antioxidant/oxidant balance in diabetic-hypercholesterolaemic rats
Author: Magdaléna Kuželová, Adriana Adameová, Zuzana Sumbalová, Ingrid Paulíková, Anna Harčárová, Pavel Švec and Jarmila Kucharská
Abstract: The effect of simvastatin administered for 10 days on coenzyme Q and antioxidant/oxidant balance in a rat model of diabetes mellitus and hypercholesterolaemia was studied.
In the diabetic-hypercholesterolaemic rats the signs of oxidative stress-decreased α-tocopherol/cholesterol in the plasma (p found. Increased coenzyme Q9 concentrations in the plasma (p p 05) and in the liver (p ation to oxidative stress. Administration of simvastatin (10 mg/kg) to the diabetic-hypercholesterolaemic rats counteracted increased myocardial (coenzyme Q10, p . Even though simvastatin treatment did not induce coenzyme Q deficiency in plasma, heart and liver of the diabetic-hypercholesterolaemic rats as compared to the control levels, it was not able to prevent completely the changes in antioxidant/oxidant balance induced by diabetes and hypercholesterolaemia. The results highlight the importance of studying the effect of statins on the coenzyme Q levels in the animal models of pathological conditions known to change the initial antioxidant defence system
Keywords: Experimental diabetic hypercholesterolaemia — Coenzyme Q — α-tocopherol — Lipid peroxidation — Simvastatin
Year: 2008, Volume: 27, Issue: 4 Page From: 291, Page To: 298


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