Home Acta Virologica 2007 Acta Virologica Vol.51, p.143-148, 2007

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.51, p.143-148, 2007

Title: SEQUENCE ANALYSIS OF THE REGIONS FLANKING TERMINAL REPEATS OF THE GENOME OF SUMAVA ISOLATE OF MURINE GAMMAHERPESVIRUS
Author: J. BLASKOVICOVA, J. TOMASKOVA, M. SUPOLIKOVA, J. MISTRIKOVA, J. KOPACEK

Abstract: The Sumava isolate of murine gammaherpesvirus (MHV-�umava) slightly differs from Murine gammaherpesvirus 68 (MHV-68) and two other isolates of murine gammaherpesvirus (MHV), MHV-76 and MHV-72 in some biological properties. To identify the region(s) in the MHV-�umava genome responsible for this phenomenon, we compared the sequences flanking terminal repeats (TRs) of the MHV-�umava genome with those of MHV-68, MHV-76 and MHV-72. Restriction and sequence analyses revealed in MHV-�umava as compared to MHV-68 a ~9.3 kbp deletion at the left end of the genome and a ~1.5 kbp deletion at the right end of the genome. While the ~9.3 kbp deletion was similar to that in MHV-76, the ~1.5 kbp deletion was unique for MHV-�umava.

Keywords: murine gammaherpesvirus; Sumava isolate; sequence analysis
Year: 2007, Volume: 51, Issue: Page From: 143, Page To: 148



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