General Physiology and Biophysics Vol.29, No.1, p.79

General Physiology and Biophysics Vol.29, No.1, p.79–84, 2010

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.29, No.1, p.79–84, 2010
Title: Alterations in adipocyte glucose transporter GLUT4 and circulating adiponectin and visfatin in rat adjuvant induced arthritis
Author: Jana Jurčovičová, Andrea Štofková, Martina Škurlová, Miroslava Baculíková, Štefan Zórad and Mária Stančíková

Abstract: Rheumatoid arthritis in humans brings about impaired insulin sensitivity and glucose tolerance. Since adipose tissue plays a role in glucose homeostasis, we evaluated the size of adipocytes, the amount of glucose transporter type 4 (GLUT4) in adipocyte plasma membranes, and circulating insulin, glucose, and adipokines affecting glucose metabolism, resistin, adiponectin and visfatin during experimental adjuvant arthritis (AA) in male Lewis rats. AA was induced by a single injection of complete Freund’s adjuvans. Adipocyte diameter was assessed microscopically, GLUT4 was measured by Western blotting. Plasma insulin, adiponectin, visfatin were quantitated by RIA, and resistin by ELISA. Arthritic rats showed cachexia, reduced adipocyte size, and downregulated membrane GLUT4 (4065 ± 962 vs. 9911 ± 680 arb. units of optic density, p

Keywords: Adjuvant arthritis — Adipocytes — GLUT4 — Visfatin — Adiponectin
Year: 2010, Volume: 29, Issue: 1	Page From: 79, Page To: 84

doi:10.4149/gpb_2010_01_79
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