Acta Virologica Vol.51, p.179-187, 2007

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.51, p.179-187, 2007
Title: REPLICATION OF JAPANESE ENCEPHALITIS VIRUS IN MOUSE BRAIN INDUCES ALTERATIONS IN LYMPHOCYTE RESPONSE
Author: Y. KAVITHA, S. THOMAS, A. DAMODARAN, L. RAMAKRISHNA, U. RANGA, R. MANJUNATH

Abstract: The experimental model using intracerebral (i.c.) challenge was employed in many studies evaluating the protection against disease induced by Japanese encephalitis virus (JEV). We investigated alterations in peripheral lymphocyte response caused by i.c. infection of mice with JEV. Splenocytes from the i.c.-infected mice showed suppressed proliferative response to concanavalin A (con A) and anti-CD3 antibody stimulation. At the same time, the expression of CD25 (IL-2R) and production of IL-2 was inhibited. Addition of anti-CD28 antibody restored the decreased anti-CD3 antibody-mediated proliferation in the splenocytes. Moreover, the number of con A-stimulated cells secreting IL-4 was significantly reduced in splenocytes from i.c.-infected mice. These studies suggested that the i.c. infection with JEV might involve additional immune modulation effects due to massive virus replication in the brain.

Keywords: Japanese encephalitis virus; intracerebral infection; immune response
Year: 2007, Volume: 51, Issue:	Page From: 179, Page To: 187


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