Home HOME General Physiology and Biophysics 2010 General Physiology and Biophysics Vol.29, No.2, p.194–202, 2010

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.29, No.2, p.194–202, 2010

Title: Central effects of ghrelin on the adrenal cortex: a morphological and hormonal study
Author: Verica Lj. Milošević, Darko M. Stevanović, Dejan M. Nešić, Branka T. Šošić-Jurjević, Vladimir Z. Ajdžanović, Vesna P. Starčević, Walter B. Severs

Abstract: Ghrelin, a growth hormone secretagogue that exerts an important role in appetite and weight regulation, participates in the activation of the hypothalamo-pituitary-adrenal (HPA) axis. Male Wistar rats (5/group) received daily for 5 days, via an ICV (intracerebroventricular) cannula, 5 µl phosphate buffered saline with or without 1 µg of rat ghrelin. Two hours after the last injection, blood and adrenal glands were collected from decapitated rats for blood hormone analyses and histologic and morphometric processing. Ghrelin treatment resulted in increased (p n precise role in the multiple networks affecting the stress hormone release, besides its well known energy and metabolic disbalance effects, remains a very important research goal.

Keywords: Ghrelin — Adrenal cortex — Aldosterone — Corticosterone — Male rats
Year: 2010, Volume: 29, Issue: 2 Page From: 194, Page To: 202

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