Home HOME General Physiology and Biophysics 2010 General Physiology and Biophysics Vol.29, No.2, p.203–207, 2010

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.29, No.2, p.203–207, 2010

Title: Mitochondrial function in heart and kidney of spontaneously hypertensive rats: influence of captopril treatment
Author: Jana Mujkošová, Oľga Uličná, Iveta Waczulíková, Jana Vlkovičová, Oľga Vančová, Miroslav Ferko, Štefan Polák, Attila Ziegelhöffer

Abstract: Effect of captopril treatment on capability of heart and kidney mitochondria to produce ATP was investigated in spontaneously hypertensive rats (SHR). Heart mitochondria from SHR responded to hypertension with tendency to compensate the elevated energy demands of cardiac cells by moderate increase in mitochondrial Mg2+-ATPase activity, membrane fluidity (MF) and in majority of functional parameters of the mitochondria (p > 0.05). Significant increase exhibited only the oxygen consumption (QO2; p crease in OPR and the ADP:O (p LUT+MAL and succinate as substrates. Captopril treatment does not alleviated but even worsened the above alterations. Mg2+-ATPase became also decreased and the depression of ADP:O became aggravated (p 

Keywords: Spontaneous hypertensive rats — Heart — Kidney — Mitochondria — Captopril
Year: 2010, Volume: 29, Issue: 2 Page From: 203, Page To: 207

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