Acta Virologica Vol.47, p.113-119, 2003

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.47, p.113-119, 2003
Title: EFFECT OF MONENSIN ON MAYARO VIRUS REPLICATION IN MONKEY KIDNEY AND AEDES ALBOPICTUS CELLS
Author: R.M. de Campos, D.F. Ferreira, V.F. da Veiga, M.A. Rebello, M.C.S. Rebello

Abstract: The effect of a cationic ionophore, monensin, on the replication of Mayaro virus in monkey kidney TC7 and Aedes albopictus cells has been studied. Treatment of these cells with 1 µmol/l monensin during infection did not affect the virus protein synthesis but inhibited severely the virus replication. Electron microscopy of the cells infected with Mayaro virus and treated with monensin revealed that the morphogenesis of Mayaro virus was impaired in TC7 but not in A. albopictus cells.

Keywords: Mayaro virus; monensin; TC7 cells; Aedes albopictus cells; protein synthesis; virus morphogenesis
Year: 2003, Volume: 47, Issue:	Page From: 113, Page To: 119


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