Home CONTACT Acta Virologica 2007 Acta Virologica Vol.51, p.265-269, 2007

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.51, p.265-269, 2007

Title: INHIBITION OF GENE EXPRESSION DIRECTED BY SMALL INTERFERING RNAS IN INFECTIOUS BRONCHITIS VIRUS
Author: H. MENG, F.Y. CUI, X.H. CHEN, Y.C. PAN

Abstract: In this study, fourteen small interfering RNAs (siRNAs) were synthesized for targeting of coding gene sequences, specific 5'-leader sequence of mRNA and 3'-end sequence of the Infectious bronchitis virus (IBV) genome. The expression of viral genes in Vero-E6 cells was detected by real-time PCR. Obtained results indicated that the majority of siRNAs could effectively inhibit the expression of viral genes. The inhibition effect of siRNAs significantly differed among various genes and sites on the virus genome.

Keywords: Infectious bronchitis virus; RNA interference; small interfering RNA; gene expression
Year: 2007, Volume: 51, Issue: Page From: 265, Page To: 269

Price: 9.00 €






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