General Physiology and Biophysics Vol.29, No.4, p.346-354, 2

General Physiology and Biophysics Vol.29, No.4, p.346-354, 2010

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.29, No.4, p.346-354, 2010
Title: Sex differences in social stress-induced pressor and behavioral responses in normotensive and hypertensive rats
Author: Iveta Bernatova, Angelika Puzserova, Michal Dubovicky

Abstract: This study investigated sex differences in chronic social stress-induced pressor and behavioral responses in normotensive and prehypertensive rats. Adult Wistar and borderline hypertensive (BH) rats (offspring of Wistar dams and spontaneously hypertensive sires) of both sexes were exposed to crowding stress (200 cm2/rat, 5 rats/cage) for 6 weeks. Controls were kept 4 rats/cage (480 cm2/rat). Blood pressure (BP) and open field activity were determined before experiment and after 1, 3 and 6 weeks of stress. Basal BP of BH rats was higher than in Wistar (p eems to represent a significant risk factor for development of stress-related hypertension only in males with genetic predisposition to high blood pressure while females of both phenotypes responded to stress by impaired between-session habituation.

Keywords: Borderline hypertension — Open field behavior — Sex differences — Habituation — Crowding
Year: 2010, Volume: 29, Issue: 4	Page From: 346, Page To: 354

doi:10.4149/gpb_2010_04_346
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