General Physiology and Biophysics Vol.29, No.4, p.414-418, 2

General Physiology and Biophysics Vol.29, No.4, p.414-418, 2010

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.29, No.4, p.414-418, 2010
Title: Expressional changes of RyR1 and RyR2 in PC12 cells after induction of apoptosis
Author: Dana Jurkovicova, Lubomira Lencesova, Olga Krizanova

Abstract: Ca2+ released from endoplasmic reticulum through ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) can trigger apoptotic or necrotic pathways in cooperation with proapoptotic and/or prosurvival proteins, as those of Bcl-2 family. In such regulatory pathways expressional modulation of these Ca2+ transporters could also be expected. Therefore, our aim was to determine the expressional changes of RyR1 and RyR2 after experimental induction of apoptosis in PC12 cells. Our results showed significant decrease of RyR1 and RyR2 expressions, while caspase-3 and Bax expression significantly increased. We conclude that induction of apoptosis in PC12 cells could result in RyR expression down regulation.

Keywords: Ryanodine receptors — Gene expression — Apoptosis — PC12 cells
Year: 2010, Volume: 29, Issue: 4	Page From: 414, Page To: 418

doi:10.4149/gpb_2010_04_414
	download file

Aepress.sk