Home General Physiology and Biophysics 2010 General Physiology and Biophysics Vol.29, No.4, p.414-418, 2010

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.29, No.4, p.414-418, 2010

Title: Expressional changes of RyR1 and RyR2 in PC12 cells after induction of apoptosis
Author: Dana Jurkovicova, Lubomira Lencesova, Olga Krizanova

Abstract: Ca2+ released from endoplasmic reticulum through ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) can trigger apoptotic or necrotic pathways in cooperation with proapoptotic and/or prosurvival proteins, as those of Bcl-2 family. In such regulatory pathways expressional modulation of these Ca2+ transporters could also be expected. Therefore, our aim was to determine the expressional changes of RyR1 and RyR2 after experimental induction of apoptosis in PC12 cells. Our results showed significant decrease of RyR1 and RyR2 expressions, while caspase-3 and Bax expression significantly increased. We conclude that induction of apoptosis in PC12 cells could result in RyR expression down regulation.

Keywords: Ryanodine receptors — Gene expression — Apoptosis — PC12 cells
Year: 2010, Volume: 29, Issue: 4 Page From: 414, Page To: 418

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