General Physiology and Biophysics Vol.29, No.4, p.419-423, 2

General Physiology and Biophysics Vol.29, No.4, p.419-423, 2010

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.29, No.4, p.419-423, 2010
Title: Removal of the outermost arginine in IVS4 segment of the CaV3.1 channel affects amplitude but not voltage dependence of gating current (Short Communication)
Author: Mária Karmažínová, Ľubica Lacinová

Abstract: Positively charged amino acids in S4 segments of voltage-dependent CaV3.1 channel form putative voltage sensor. Previously we have shown that exchange of uppermost positively charged arginine in IVS4 segment for cysteine (mutation R1717C) affected deactivation and inactivation, but not activation of macroscopic current. Now we compared gating currents from both channels. Maximal amplitude of charge movement in R1717C channel decreased but voltage-dependent characteristics of charge movement were not significantly altered. We concluded that mutation of R1717C affects the coupling between S4 activation and pore opening, but not the S4 activation itself.

Keywords: T-type calcium channel — Charge movement — CaV3.1 channel — S4 segment — Channel gating
Year: 2010, Volume: 29, Issue: 4	Page From: 419, Page To: 423

doi:10.4149/gpb_2010_04_419
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