Acta Virologica Vol.52, No.3, p.151-159, 2008

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.52, No.3, p.151-159, 2008
Title: IDENTIFICATION OF TUMOR NECROSIS FACTOR SIGNALINGRELATED PROTEINS DURING EPSTEIN-BARR VIRUS-INDUCED B CELL TRANSFORMATION
Author: J.P. JEON, J.W. KIM, B. PARK, H.Y. NAM, S.M. SHIM, M.H. LEE, B.G. HAN

Abstract: Epstein-Barr virus (EBV) infection in vitro transforms primary B cells into continuously proliferating lymphoblastoid cell lines (LCLs) that have been widely used as a genomic resource for variety of immunological and genetic studies. However, the biochemical and biological characteristics that distinguish LCLs from the B cells have not been thoroughly investigated. Our proteomic approach showed that EBV infection induced changes in the profiles of tumor necrosis factor (TNF) signaling-related proteins in LCLs including heat shock protein family members TNF receptor-associated protein 1 (TRAP-1), heat shock 70-kDa protein 9 (HSPA9)) and superoxide dismutase 2 (SOD2). In addition, our literature co-occurrence study placed TNF at the center of a gene cluster network of differentially expressed proteins in LCLs. This study suggested that deregulation of TNF signaling pathway could contribute to the cellular transformation and immortalization of the EBV-infected B cells.

Keywords: Epstein-Barr virus; lymphoblastoid cell line; proteomics; tumor necrosis factor
Year: 2008, Volume: 52, Issue: 3	Page From: 151, Page To: 159


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