Journal info
Aims and Scope |
||
Select Journal
Journals
Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.52, No.3, p.181-184, 2008 |
||
Title: POST-REASSORTMENT AMINO ACID CHANGE IN THE HEMAGGLUTININ OF A HUMAN-AVIAN INFLUENZA H5N1 REASSORTANT VIRUS ALTERS ITS ANTIGENIC SPECIFICITY | ||
Author: I.A. RUDNEVA, T.A. TIMOFEEVA, N.A. ILYUSHINA, N.L. VARICH, K.S. KOCHERGIN-NIKITSKY, N.V. KAVERIN | ||
Abstract: It was shown earlier that the reassortant influenza virus having hemagglutinin (HA) gene of A/Duck/Primorie/2621/2001 (H5N2) virus and 7 genes of A/Puerto Rico/8/34 (H1N1) virus produced low yields in embryonated chicken eggs. We found that a variant reassortant selected by serial passages in eggs produced higher yields than the initial reassortant. The variant reassortant had an amino acid substitution in the hemagglutinin N244D (H3 numbering). In this report we demonstrated that the post-reassortment amino acid substitution N244D altered the antigenic specificity of HA as revealed by the loss of reactivity with an anti-H5 monoclonal antibody in hemagglutination-inhibition (HI) test. The results are discussed in association with the evolution of H5 hemagglutinin. |
||
Keywords: influenza virus; reassortment; amino acid change; antigenic specificity | ||
Year: 2008, Volume: 52, Issue: 3 | Page From: 181, Page To: 184 | |
Price:
9.60 €
|
||
|
||