Acta Virologica Vol.47, p.201-215, 2003

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.47, p.201-215, 2003
Title: THE HUMAN INTERFERON SYSTEM: CHARACTERIZATION AND CLASSIFICATION AFTER DISCOVERY OF NOVEL MEMBERS
Author: P. KONTSEK, G. KARAYIANNI-VASCONCELOS, E. KONTSEKOVÁ

Abstract: The human interferon (IFN) system is the best characterized of all animal IFN systems. Until recently it is thought that all IFNs and IFN-related genes and proteins have been discovered. However, in the last three years, the discovery and characterization of IFNs including IFN-epsilon (IFN-e), IFN-kappa (IFN-k) and a novel IFN-lambda (IFN-l) family, in particular, substantially changed this opinion. In this article, we attempt to review recent developments in the field of interferon discovery and present an overview of current classification of the human IFN system. Characterization of the constituent parts of the human IFN system including ligands, receptors and players involved in the signal transduction pathway are discussed.

Keywords: cytokine; dsRNA IFN family; IFN gene; IFN ligand; IFN polypeptide; IFN receptor; IFN signaling; IFN subgroup; IFN type; IFNAR; IFNGR; IFNLR; JAK-STAT; signal transduction
Year: 2003, Volume: 47, Issue:	Page From: 201, Page To: 215


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