Home Acta Virologica 2003 Acta Virologica Vol.47, p.217-221, 2003

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.47, p.217-221, 2003

Title: ENHANCEMENT OF IMMUNE RESPONSES TO THE HEPATITIS B VIRUS CORE PROTEIN THROUGH DNA VACCINES WITH A DNA FRAGMENT ENCODING HUMAN IL-1B 163–171 PEPTIDE
Author: H.J. SHAO, L. CHEN, M.S. SHEN, G.F. YU

Abstract: DNA vaccines have been widely used as effective means of eradicating a variety of viruses, parasites, bacteria as well as means of alleviating allergic and autoimmune diseases and tumors. As interleukin 1 (IL-1) plays an essential role in augmenting both cellular and humoral immune responses to foreign antigens, it may represent a good candidate for an adjuvant to DNA vaccines. Since the inflammatory activity of IL-1 may have a restricted application to DNA vaccines, we explored the possibility of augmenting immune response without unwanted inflammatory effect using IL-1b 163–171 peptide, which is essential for IL-1 receptor 1 binding. A DNA fragment encoding the human IL-1b 163–171 peptide of concern was fused to the Hepatitis B virus (HBV) core DNA vaccine, and injected into mice to analyze its immune responses. Compared with the control mice which received hepatitis B virus core antigen (HBcAg) alone, significant increase in not only the HBcAg-specific antibody response but also in T cell proliferation was observed in mice which received IL-1b 163–171-HBcAg. These results suggest that the DNA fragment encoding the IL-1b polypeptide of aa 163–171 might represent a good candidate for an adjuvant of DNA vaccines.

Keywords: interleukin 1b; hepatitis B virus core antigen; DNA vaccine
Year: 2003, Volume: 47, Issue: Page From: 217, Page To: 221



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