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Endocrine Regulations 2005 Endocrine Regulations Vol.39, p.7-11, 2005
Endocrine Regulations 2005 Endocrine Regulations Vol.39, p.7-11, 2005
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Endocrine Regulations Vol.39, p.7-11, 2005 |
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| Title: EFFECT OF THE GROWTH HORMONE-RELEASING HORMONE [GHRH(1-44)NH2] ON IL-6 AND IL-8 SECRETION FROM HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO | ||
| Author: A. SIEJKA, T. STEPIEN, H. LAWNICKA, R. KRUPINSKI, J. KOMOROWSKI, H. STEPIEN | ||
| Abstract: Objective. Bidirectional communication between the neuroendocrine and immune systems is now a subject of an intensive investigation. Growth hormone-releasing hormone (GHRH) is synthesized by the hypothalamus, but is present also in the immune cells. Some recent data indicate also an immunomodulatory role of the neuropeptide. The aim of the study was to examine the influence of GHRH(1-44)NH2 on interleukin-6 and interleukin-8 secretion from human peripheral blood mononuclear cells cultured in vitro. Methods. Peripheral blood mononuclear cells (PBMC) were isolated by centrifugation using Böyum technique and cultured in a humidified atmosphere of 5 % CO2 and 95 % O2 at 37 0C for 24 hours in the presence of lipopolysaccharide (LPS) at the concentration of 2 µg/ml and GHRH(1-44)NH2 (the final neuropeptide concentrations to be tested were 10-12 to 10-6 M). ELISA methods were used to measure IL-6 and IL-8 concentrations in the supernatants of cultured cells Results. GHRH(1-44)NH2 influenced IL-6 secretion from cultured cells, but significant inhibition of IL-6 release was observed at 10-6 M (p |
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| Keywords: Growth hormone – releasing hormone – Interleukin-6 – Interleukin-8 – Neuroimmunomodulation | ||
| Year: 2005, Volume: 39, Issue: 1 | Page From: 7, Page To: 11 | |
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