Home Acta Virologica 2004 Acta Virologica Vol.48, p.79-83, 2004

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Impact Factor = 1.82

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Acta Virologica Vol.48, p.79-83, 2004

Title: MOLECULAR CHARACTERIZATION OF AN INFECTIOUS BURSAL DISEASE VIRUS ISOLATE FROM IRAN
Author: S.D. HOSSEINI, A.R. OMAR, I. AINI

Abstract: The segment A of an Infectious bursal disease virus (IBDV) isolate from Iran was amplified by reverse transcription–polymerase chain reaction (RT-PCR), sequenced and compared with published sequences of 26 IBDV isolates from other parts of the world. The Iranian isolate showed 8 unique amino acid differences. In addition, 9 common amino acid differences, namely 3 in VP2, (222 Ala, 256 lIe and 294 lIe), 3 in VP4 (685 Asn/Ser, 715 Ser and 751 Asp), 2 in VP3 (990 Val and 1005 Ala), and 1 in VP5 (49 Arg) were found. Phylogenetic analysis indicated that the Iranian isolate is closely related to highly virulent (hv) IBDV isolates from Asian countries. Nevertheless, it may share a common origin with hv isolates from other parts of the world.

Keywords: Infectious bursal disease virus; segment A; RT-PCR; nucleotide sequence; phylogenetic analysis
Year: 2004, Volume: 48, Issue: Page From: 79, Page To: 83



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