Endocrine Regulations Vol.37, p.31-44, 2003

Quarterly, 50 pp. per issue
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.37, p.31-44, 2003
Title: OSTEOPOROSIS: GENETIC ANALYSIS OF MULTIFACTORIAL DISEASE
Author: Katerina Zajickova, Ivana.Žofkova

Abstract: Osteoporosis is a common disorder with a complex pathophysiology involving both endogenous and environmental factors. Family and twin studies have shown that genetic factors play an essential role in bone mass regulation and that apart from rare instances the heritability of bone mineral density (BMD) and osteoporosis is polygenic. Linkage analysis and association studies with numerous DNA markers (single nucleotide polymorphisms or microsatellites) have analysed several bone-related candidate genes encoding vitamin D, calcium-sensing, calcitonin and estrogen alpha receptors, insulin growth factor I, collagen type I alpha 1 chain and others. Despite this, the definite polymorphic marker has not been found in different populations which reflects the divergent results of association studies with their frequent limitations, and probably the fact that the relevant polymorphism is still awaiting identification. Once the genetic determinants can be defined, the clinical implications would be extensive both in diagnostics and in pharmacogenetics.

Keywords: Osteoporosis – Bone mineral density – Candidate genes – DNA polymorphisms – Association studies
Year: 2003, Volume: 37, Issue:	Page From: 31, Page To: 44


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