General Physiology and Biophysics Vol.26, p.27-32, 2007

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.26, p.27-32, 2007
Title: Cardiovascular diseases and molecular variants of the renin-angiotensin system components in Slovak population
Author: D. Jurkovicova, B. Sedlakova, I. Riecansky, E. Goncalvesova, A. Penesova, R. Kvetnansky, O. Krizanova

Abstract: Cardiovascular diseases associated with molecular variants of individual components of renin-angiotensin system are reported to constitute inherited predisposition in humans. Molecular variant frequencies are race- and population-dependent. We examined frequencies of the M235T variant of angiotensinogen gene and I/D polymorphism of gene for angiotensin-converting enzyme in Slovak population: in hypertensive patients, coronary heart disease (CHD), dilated cardiomyopathy (DCM) and myocardial infarction (MI) patients compared to healthy subjects. Frequency of M235T was significantly increased in hypertensive, CHD and DCM patients compared to controls (0.48 and 0.50 vs. 0.40, p

Keywords: Polymorphisms — Hypertension — Coronary heart disease — Dilated cardiomyopathy — Slovak population
Year: 2007, Volume: 26, Issue:	Page From: 27, Page To: 32


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