General Physiology and Biophysics Vol.26, p.97-103, 2007

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.26, p.97-103, 2007
Title: Antioxidant properties of carotenoids: QSAR prediction of their redox potentials
Author: M. Kleinova, M. Hewitt, V. Brezova, J. C. Madden, M. T. D. Cronin, M. Valko

Abstract: There is a great need to predict the antioxidant properties of molecules such as carotenoids. These compounds are of great interest due to their contribution to various important biological and industrial processes, including toxicity and fate. In our study, redox potentials were compiled from several literature sources. Redox potential values ranged from 537.2 mV for zeaxanthin up to 691.5 mV for β-carotene; they correspond to the formation of cation radicals, using the standard calomel electrode (SCE). The redox potential values were measured using conventional electrochemical techniques, cyclic voltammetry and Osteryoung square-wave voltammetry. A quantitative structureactivity relationship (QSAR) was developed to model and consequently to predict the values of redox potential. The predicted values of redox potential for four external carotenoids, namely β-carotene, zeaxanthin, cantaxanthin and astaxanthin, are presented and discussed. They indicate the dependence of redox potential on structure, donor and acceptor groups and polarisability.

Keywords: QSAR(s) — Carotenoids — Redox potential — Antioxidant properties
Year: 2007, Volume: 26, Issue:	Page From: 97, Page To: 103


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