General Physiology and Biophysics Vol.26, p.104-109, 2007

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.26, p.104-109, 2007
Title: Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K
Author: Y. Feng, H. Q. Cao, Z. Liu, J. F. Ding. X. M. Meng

Abstract: Molecular cloning of cardiac troponin I-interacting kinase (TNNI3K), a novel cardiacspecific protein kinase containing seven N-terminal ankyrin (ANK) repeats followed by a protein kinase domain and a C-terminal Ser-rich domain, has previously been reported. In the present study, we show that the C-terminal functional region of TNNI3K negatively regulates the kinase activity, and the N-terminal ANK domain is necessary for autophosphorylation. An in vitro kinase assay shows that TNNI3K exhibits dual-specific kinase activity and forms dimers or oligomers that may be necessary for its activation.

Keywords: Protein kinase — Mixed lineage kinase — Cardiac troponin I-interacting kinase — Ankyrin repeats — Ser-rich domain
Year: 2007, Volume: 26, Issue:	Page From: 104, Page To: 109


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