General Physiology and Biophysics Vol.26, p.110-117, 2007

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.26, p.110-117, 2007
Title: Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions
Author: M. Novakova, V. Bruderova, Z. Sulova, J. Kopacek, L. Lacinova, R. Kvetnansky, A. Vasku,P. Kaplan, O. Krizanova, D. Jurkovicova

Abstract: The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptor’s mRNA levels. Signalling cascade of sigma receptors is dependent on IP3 receptors, since silencing of both, type 1 and 2 IP3 receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.

Keywords: Sigma receptors — IP3 receptors — Stress — Gene expression
Year: 2007, Volume: 26, Issue:	Page From: 110, Page To: 117


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