General Physiology and Biophysics Vol.26, p.173-180, 2007

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.26, p.173-180, 2007
Title: Evaluation of novel microtubules interfering agents myoseverin, tubulyzine and E2GG in primary cultures of rat hepatocytes
Author: Z. Dvorak, M. Modriansky, J. Vrba1, J. Ulrichova1, V. Krystof, J. Styskala, P. Pavek

Abstract: We investigated the effects of novel microtubules interfering agents (MIAs) in primary cultures of rat hepatocytes. Cells were treated for 24 h with a known compound colchicine and newly synthesized derivatives myoseverin, tubulyzine, and E2GG. We examined the effects of MIAs on microtubules network integrity and on the polymerization capability of isolated tubulin. All tested MIAs inhibited microtubules assembly with the following IC50 values: tubulyzine (4.4 ± 0.9 μmol/l), myoseverin (7.0 ± 0.8 μmol/l), E2GG (16 ± 2 μmol/l), colchicine (2.0 ± 0.4 μmol/l). The potency of MIAs to perturb microtubular network integrity (monitored by immune-histochemistry) increased in the order tubulyzine

Keywords: Microtubule — Tubulin polymerization — Cytochrome P450 — Cellular signaling — Myoseverin — Tubulyzine
Year: 2007, Volume: 26, Issue:	Page From: 173, Page To: 180


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