Home General Physiology and Biophysics 2007 General Physiology and Biophysics Vol.26, p.207-213, 2007

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.26, p.207-213, 2007

Title: Effect of the pyridoindole antioxidant stobadine on ATP-utilisation by renal Na,K-ATPase in rats with streptozotocin-induced diabetes
Author: N. Vrbjar, S. Strelkova, V. Javorkova, J. Vlkovicova, L. Mezesova, M. Stefek, Z. Kyselova, A. Gajdosikova
Abstract: The effect of the pyridoindole antioxidant stobadine on diabetes-induced changes of Na,KATPase, especially those concerning the utilisation of its substrate ATP, was investigated. Sixteen weeks of streptozotocin-induced diabetes (single i.v. dose of streptozotocin; 55 mg/kg) was followed by decrease in the enzyme activity. This effect was emphasised in the presence of higher concentrations of substrate and in the presence of 8 mmol·l–1 ATP it represented 20%. It might be a consequence of altered functional properties of Na,K-ATPase as suggested by 20% decrease in the Vmax value along with decrease in the Km value by 20%. Administration of 0.05% (w/w) stobadine in the diet to diabetic rats improved the function of renal Na,K-ATPase with respect to utilisation of ATP as suggested by significant increase in the enzyme activity in the whole concentration range of ATP investigated as a consequence of Vmax elevation to the level comparable to absolute controls. In conclusion, stobadine may play a positive role in restoring the functional properties of renal Na,K-ATPase, especially concerning the utilisation of energy derived from hydrolysis of ATP, improving thus the maintenance of ionic homeostasis during diabetes.
Keywords: Sodium-pump — Kidney — Diabetes — Stobadine
Year: 2007, Volume: 26, Issue: Page From: 207, Page To: 213


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