Home General Physiology and Biophysics 2007 General Physiology and Biophysics Vol.26, p.221-229, 2007

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.26, p.221-229, 2007

Title: Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue
Author: E. Pravdova, L. Macho, N. Hlavacova, M. Fickova
Abstract: Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker. Impact of ethanol intake on resistin level and resistin metabolic effects is unknown. Effect of long-time (28 days) ad libitum moderate alcohol (6% ethanol solution) intake on serum resistin and resistin mRNA level in adipose tissue of rats (A) was compared to control (C) and pair-fed (PF) animals. PF rats were fed the same caloric amount as A rats on previous day. Alcohol consumption resulted in reduction of food and energy intake, decreased body mass gain, epididymal fat pads mass and smaller adipocytes (vs. C rats). Alcohol intake significantly increased serum resistin and glucose, insulinemia remained unchanged. Systemic insulin resistance was not proved by HOMA, QUICKI and McAuley indexes, but impaired insulin effect on glucose transport in isolated adipocytes was present. Elevated serum resistin was positively correlated with glycemia (r = 0.88, p
Keywords: Resistin — Alcohol — Insulin resistance — Adipocytes — Glucose transport
Year: 2007, Volume: 26, Issue: Page From: 221, Page To: 229


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