Home General Physiology and Biophysics 2007 General Physiology and Biophysics Vol.26, p.230-233, 2007

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.26, p.230-233, 2007

Title: Angiopoietin-like protein 3: development, analytical characterization, and clinical testing of a New ELISA
Author: D. Stejskal, M. Karpisek, V. Humenanska, P. Solichova, P. Stejskal
Abstract: The aim of our work was to develop an assay for the determination of angiopoietinlike protein 3 (Angptl3) in human blood, and investigate its levels in healthy volunteers and donors suffer from metabolic syndrome and familiar hypercholesterolemia. We developed and evaluated the sandwich ELISA method for the quantitative determination of human Angptl3 in serum samples. We conducted also the pilot study on individuals with metabolic syndrome or familiar hypercholesterolemia and healthy probands. The following parameters were measured: blood pressure, waist circumference, Angptl3 serum levels, serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, insulin, glucose, A-FABP, and BMI and Quicki insulin sensitivity index was calculated. In the study on 93 healthy volunteers we demonstrated that sex or age is not the determinant for Angptl3 serum values. Futhermore, 118 individuals with metabolic syndrome and 200 patients with familiar hypercholesterolemia were tested and it was found that probands with metabolic syndrome or familiar hypercholesterolemia had higher Angptl3 values than healthy individuals from the first study (medians 289.5 vs. 277.1 vs. 224.8 ng/ml, p
Keywords: Angiopoietin-like protein 3 — ELISA — Metabolic syndrome — Triglycerides
Year: 2007, Volume: 26, Issue: Page From: 230, Page To: 233


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