General Physiology and Biophysics Vol.26, p.234-239, 2007

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.26, p.234-239, 2007
Title: Monovalent currents through the T-type Cav3.1 channels and their block by Mg2+
Author: M. Kurejova, M. Pavlovicova and L. Lacinova

Abstract: We have investigated the permeability of the Cav3.1 channel for Ca2+ and different monovalent cations and the block of the currents by Mg2+ ions. In the absence of extracellular divalent cations, the Cav3.1 channel was more permeable for Na+ than for Cs+ and impermeable for NMDG+. Monovalent currents were inhibited by Mg2+ of near physiological concentration by three orders of magnitude more effectively than the Ca2+ current. Inhibition of outward, but not inward current by Mg2+ was voltage-dependent. Furthermore, magnesium slowed down channel deactivation presumably by interacting with an open channel state.

Keywords: T-type calcium channel — Cav3.1 — Monovalent cations — Permeability
Year: 2007, Volume: 26, Issue:	Page From: 234, Page To: 239


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